Aging and Disease
Homeostatic DNMT3a Activity Is Required to Restore Cognition and Hippocampal DNA Methylation in the 5xFAD Model of Alzheimer's Disease
Experiments in animalsInterventions
Abstract
Dysregulation of DNA methylation has been implicated in Alzheimer's disease (AD), making the manipulation of DNA methylation processes a promising therapeutic strategy. DNA methyltransferase 3a (DNMT3a), one of the two de novo DNMTs, is involved in learning and memory.
The paper
University of Hong Kong; Hubei University of Medicine
Aging and Disease, 20 Jun 2025, CC BY
