Low handgrip strength is associated with higher cancer prevalence in frail nonagenarians and centenarians

It is known that muscle strength is associated with adverse health outcomes associated with cancer-related symptoms. The purpose of this study was to investigate the association between handgrip strength and cancer in frail oldest old. In this prospective cohort study, 81 nonagenarians and centenarians were included [mean age (SD): 94.2 (3.8) years]. Data related to prevalent cancer were self-reported and global strength was assessed by handgrip strength. Logistic regressions were calculated for age- and sex-specific tertiles of relative grip strength, with participants in the highest tertile considered as the reference group. The χ² test was used to assess differences in tertile categories of normalized handgrip strength between groups (i.e., cancer diagnoses or not). Significant differences were obtained for normalized handgrip strength tertile categories between groups: older adults without a diagnosis of cancer had higher handgrip strength values than peers with cancer (p = 0.039). Of those with cancer, 50% were classified in tertile 1, 36% in tertile 2 and 14% in tertile 3. Considering those without a diagnosis of cancer, 27% were in tertile 1, 32% in tertile 2 and 41% in tertile 3. Low handgrip strength is associated with higher cancer prevalence in frail nonagenarians and centenarians.