Model predicted cognitive risk in adults with high blood pressure
The model scored 0.870–0.871 for ranking cognitive risk, versus 0.855–0.857 for a model using initial clinical information alone.
Our read
Biomarkers- Studied:
- Cohort study of 8,562 adults with hypertension
- What changed:
- Cognitive-risk ranking scores were higher with the dynamic model: 0.870–0.871 against 0.855–0.857 using initial clinical information alone
- The catch:
- The model lacks external validation beyond SPRINT-MIND
- In the record:
- The 61st paper on intensive blood pressure control with results in people; 85 on record in all.
Editor of record: Boris Djordjevic · AgingResearch.News
Data from 8,562 adults with hypertension in SPRINT-MIND were used in a prediction-model study of five-year risk of mild cognitive impairment or probable dementia. Mild cognitive impairment means memory or thinking problems milder than dementia.
The researchers built models using measurements available at baseline and at 3, 12 and 24 months. They combined blood pressure patterns with measures of blood vessel aging, kidney function, adverse events, walking and cognitive performance. The analysis accounted for death as a competing outcome. A separate analysis estimated that intensive rather than standard blood pressure control added an average 13.1 days free of these cognitive outcomes.
Why it matters
Dementia prevention raises the question of who may benefit most from intensive blood pressure control. The authors propose the model as a way to estimate those individual benefits.
Caveats
The model was validated only within SPRINT-MIND; its performance in other populations still needs testing. The report is a conference abstract.
- Intensive blood pressure control
- Machine learning
- Blood pressure
- Hypertension
- Mild cognitive impairment
- Humans
The paper
University of South Florida; Brooklyn Hospital Center
AHA Scientific Sessions 2026 Abstract, Nov 2, 2026
Presented at AHA Scientific Sessions 2026, abstract 19255
Comments
Be the first to comment.