Unraveling the Underlying Mechanisms of Loneliness, Social Isolation, and Cognitive Decline: A Systematic Review

GSA 2025 Abstract

Abstract

Despite extensive evidence linking loneliness and social isolation to cognitive decline in later life, the underlying pathophysiological and psychosocial mechanisms remain unclear. This systematic review synthesizes existing research to clarify these pathways.

The paper

The University of Texas Southwestern Medical Center · Harvard University

GSA 2025 Abstract · 31 Dec 2025 · CC BY

Presented at GSA 2025

doi.org/10.1093/geroni/igaf122.905