Noradrenergic Locus Coeruleus Hyperactivity Alters Attention in Cognitively Healthy Older Adults

Abstract

Animal models of Alzheimer’s disease have shown that neuropathology in the locus coeruleus (LC) leads to increased neuronal firing, while human studies demonstrate that age-related dysregulation of the LC-noradrenaline (LC-NA) system is associated with cognitive decline.