SEX- AND AGE-SPECIFIC METABOLIC EFFECTS OF EARLY-LIFE RAPAMYCIN TREATMENT IN UM-HET3 MICE

Abstract

UM-HET3 mice were treated with rapamycin (4 mg/kg, i.p., 3 times/week) from 15 to 56 days of age. At day 15, no significant differences in body weight (BW) between the treatment and control groups within each sex. During the treatment, males in the treated group consistently had lower BW than controls (pairwise-t test, P < 0.