IGF1R VARIANT R407H PREVENTS COGNITIVE IMPAIRMENT AND NEUROINFLAMMATION IN CRISPR MICE WITH AAV AB42 AND PTAU

Abstract

Late-onset Alzheimer’s disease (AD) is an age-related disease. The geroscience concept dictates that interventions that slow aging should also slow age-related diseases. This concept was tested in C57BL/6 mice expressing a CRISPr engineered IGF1R variant R407H shown to be enriched in centenarians.

The paper