Young adults’ health-risk stage linked to heart events and death
Stage 2 cardiovascular-kidney-metabolic syndrome was associated with higher relative rates of major cardiovascular events than stage 0, with a hazard ratio of 3.03.
Limit: The conference abstract did not define the stages or provide absolute event rates
Edited by Boris Djordjevic · AgingResearch.News
In a prospective observational study, researchers followed 2,998 adults aged 28–39 for a median of 24.16 years. They classified participants by cardiovascular-kidney-metabolic syndrome stage, which groups heart, kidney and metabolic health risks. Metabolic health concerns how the body processes and uses energy. During follow-up, 192 major heart and blood vessel events and 236 deaths occurred.
Compared with stage 0, stage 2 was associated with higher relative event rates: hazard ratios of 3.03 for major cardiovascular events and 1.81 for death from any cause. Stage 1 showed no statistically significant association with either outcome after adjustment for other factors. Among 1,462 participants initially at stage 0 or 1, stage 1 was linked to 1.69 times the risk of reaching stage 2 or higher in middle age, measured more than 10 years later.
Why it matters
Heart, kidney and metabolic health in young adulthood provide a starting point for investigating when cardiovascular risks associated with later-life illness become apparent.
Caveats
This observational study cannot show that syndrome stage caused later events. The conference abstract did not define the stages or provide absolute event rates for each group.
