Medial temporal lobe‐cortical connectivity is lower in older adults of African ancestry with the ABCA7‐80 risk allele but not in APOE‐ε4 carriers

Abstract

Background: APOE‐ε4 and ABCA7‐80 (rs115550680) are two prominent genetic risk factors for Alzheimer’s disease (AD). While APOE‐ε4 is the most common genetic risk factor for AD in people of European ancestry, ABCA7‐80 is linked to late‐onset AD in individuals of African ancestry.