Mendelian randomization implicates blood lipids as an actionable mediator of the effect of basal metabolic rate on Alzheimer's disease

Abstract

Background: Alzheimer's disease (AD) is a serious global health burden that disproportionately affects populations with low basal metabolic rate (BMR). This study aimed to obtain causal estimates of the association between BMR and AD and to quantify the mediating effects of known modifiable risk factors.