AAIC 2025 Abstract
PAR4 misexpression in the cerebrovasculature drives excess fibrin deposition in 5XFAD mouse and cognitive decline in AD patients
Experiments in animalsMechanisms
Abstract
Background: Platelet activation may be a central mediator of a chain of events leading to microinfarcts, leakage of thrombin and fibrin through the blood‐brain barrier and chronic neuroinflammation that typify Alzheimer’s Disease (AD).
