Adult Renal Dysfunction and Risk of Dementia or Cognitive Decline: Brain‐Kidney Axis Hypothesis Based on a Systematic Review and Meta‐Analysis

Abstract

Background: The brain‐kidney axis was proposed to emphasize roles of kidney functioning in modulating neurodegeneration. Method: The PubMed, EMBASE, and Cochrane library were searched until February 1st, 2022, to include longitudinal studies. Multivariate adjusted effects were pooled by random‐effects models.