PAK1 inhibitor NVS‐PAK1‐1 inhibits degeneration of synaptic spines in cultured neurons exposed to amyloid or tau and in 5XFAD mice following oral administration

Abstract

Background: In Alzheimer’s disease (AD), degeneration of synapses, including synaptic spines, is highly correlated with loss of cognition. p21‐activated kinase 1 (PAK1) modulates cofilin, an actin‐binding protein regulating spine integrity.

The paper