Cognitive Reserve is Associated with Entorhinal Cortex Tau Burden in an Older, Cognitively Unimpaired Clinical Trial Cohort (U.S. POINTER)

Abstract

Background: High cognitive reserve (CR) is associated with a reduced dementia risk. and better cognitive performance for given levels of Alzheimer's disease (AD) pathology. We hypothesized that CR is associated with baseline amyloid and tau pathology in the U . S .