Large‐scale cerebrospinal fluid proteomics identifies molecular signatures of disease progression across Alzheimer's disease and sporadic frontotemporal lobar degeneration

Abstract

Background: Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and other neurodegenerative diseases are characterized by pathological protein misfolding, yet postmortem neuropathological measures collectively explain less than half the variance in antemortem clinical progression.

The paper