Introduction of APP induces bioenergetic deficits within an aged humanized APOE risk model of Alzheimer's disease: An FDG‐PET analysis

Abstract

Background: Late‐onset Alzheimer's disease (LOAD) affects approximately 95% of the clinical dementia population aged 65 and older, influenced by genetics, age and sex. Apolipoprotein e4 (APOE4) is the strongest genetic risk factor, in addition to other prominent risk genes such as amyloid precursor protein (APP).