BrainAge moderates associations between AD biomarkers and cognitive decline: findings from A4/LEARN and the Harvard Aging Brain Study

Abstract

Background: BrainAge models estimate biological brain age based on neuroimaging data, providing a measure of brain health. This metric is particularly relevant in Alzheimer's disease (AD), where accelerated brain aging is exacerbated by β‐amyloid (Aβ) and tau accumulation.