AAIC 2025 Abstract

The Binding Patterns of Neurofibrillary Tangles Observed With High‐Resolution Autoradiography of ¹⁸ F MK 6240 and ¹⁸ F AV1451 Are Comparable and Predominantly Recognize Tangles at the Middle Stage

Study in peopleBiomarkers

Abstract

Background: An intense search is underway for tau PET tracers with enhanced capability to visualize tau aggregates. Research indicates that [18F] AV1451 and [18F]MK 6240 exhibit comparable binding properties in terms of spatial distribution and severity of tau aggregates, as observed both in‐vivo and in‐vitro.

The paper