AAIC 2025 Abstract
Alpha‐Synuclein Pathology in Down Syndrome‐Associated Alzheimer's Disease: Insights from Seed Amplification Assay and Neuropathology
By Íñigo Rodríguez-Baz, Alexander Maximilian Bernhardt, Ibán Aldecoa, Show 26 more authorsJohannes Levin
Study in peopleBiomarkers
Abstract
Background: Down syndrome (DS) is a genetic cause of Alzheimer's disease (AD), with virtually all individuals developing AD pathology by their fourth decade due to Amyloid Precursor Protein (APP) gene overexpression.
