Tau Spatial Extent Outperforms Tau Load as a Marker of Neocortical Tau Burden: Head‐to‐head evidence from [18F]MK6240 and [18F]FTP PET

Abstract

Background: The 2024 NIA‐AA criteria propose an Alzheimer's disease (AD) staging system based on medial temporal (MT) and neocortical tau burden. However, the optimal strategy to assess tau burden in these regions, which represent distinct phases of AD pathophysiology, remains unclear.

The paper