Retinal layer thickness as biomarker for cognitive decline in rhesus macaques

Abstract

Background: Retinal layer thinning measured by optical coherence tomography (OCT) has been proposed as a noninvasive biomarker for central nervous system degeneration, including Alzheimer's disease (AD). Non‐human primates (NHPs), whose brains and retinas closely resemble those of humans, offer a promising model for preclinical testing.