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AAIC 2025 Abstract

Increased Extra‐Synaptic Localisation of the Presynaptic Protein, SV2A, in the Human Alzheimer's Disease Brain

By Stanley Williams, Samrah Siddiqi, Sulin Liu, Show 5 more authorsJohanna Jackson
Study in peopleMechanisms
Paper

Abstract

Background: Synapse loss is a key component of Alzheimer's Disease (AD) and correlates with cognitive impairment. PET tracer, UCB‐J, binds to pre‐synaptic protein SV2a and is a potential biomarker of synapse density.

The paper

Stanley Williams, Samrah Siddiqi, Sulin Liu, Show 5 more authorsJohanna Jackson

UK Dementia Research Institute

AAIC 2025 Abstract, 24 Dec 2025, CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70856_099018

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