Meta‐Analysis of Mean Differences and Diagnostic Accuracy of Ptau‐217 in Amyloid‐Positive and Amyloid‐Negative Cognitively Unimpaired Older Adults

Abstract

Background: Plasma markers of phosphorylated tau‐217 (ptau‐217) correlate well with in‐vivo AD pathology, however it is unclear how well this assay can differentiate cognitively unimpaired (CU) older adults who do and do not have AD pathology.