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AAIC 2025 Abstract

Reduced cholinergic tone and hippocampal‐dependent cognitive impairments in APP NL‐F mice

By Alycia M Crooks, Kate M. Onuska, Taylor W. Schmitz, Show 3 more authorsMarco AM Prado
Experiments in animalsMechanisms
Paper

Abstract

Background: The prevailing model of Alzheimer's disease (AD) proposes that the accumulation of misfolded amyloid‐beta (Aβ) peptides drives tau protein hyperphosphorylation and neuroinflammation, leading to neurodegeneration and cognitive decline.

The paper

Alycia M Crooks, Kate M. Onuska, Taylor W. Schmitz, Show 3 more authorsMarco AM Prado

Western University

AAIC 2025 Abstract, 24 Dec 2025, CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70855_107535

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