AAIC 2025 Abstract
Ancestry‐informed fine‐mapping and sequence analysis of the BIN1 locus pinpoints rs6733839 as a causative variant shared between individuals of European and African ancestry with non‐Mendelian early‐onset Alzheimer's Disease
By Nicholas R. Ray, Jiji Thulaseedhara Kurup, Joseph L. Bradley, Show 2 more authorsChristiane Reitz
Study in peopleMechanisms
Abstract
Background: Genome‐wide association studies (GWAS) of complex traits often implicate genetic loci spanning thousands of variants. Statistical fine‐mapping refines a GWAS locus to a smaller set of likely causal variants facilitating interpretation and functional validation.
