Sleep‐wake variation in body temperature regulates tau phosphorylation, secretion and splicing

Abstract

Background: Aggregates of hyperphosphorylated tau protein are a hallmark of Alzheimer's disease (AD) and other tauopathies. Sleep disturbances—common in AD—have been associated with altered tau phosphorylation and secretion in both animal models and humans, and insufficient sleep is recognized as a potential risk factor for AD.

The paper