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Women with Down syndrome show more severe Alzheimer's disease neuropathology with regional differences
AAIC 2025 Abstract
Abstract
Background: Biological sex affects Alzheimer's disease (AD) progression in the neurotypical population, with women showing more rapid tau accumulation. People with Down syndrome (DS) develop AD neuropathology by the age of 40 years and represent the most common genetic cause of AD.
The paper
Elizabeth J. Andrews, Phong T. Ngo, Jesse R. Pascual, Elizabeth Head
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Freddy Gonzalez, Michael J Phelan, Sierra T. Wright, J Harp, Frederick A. Schmitt, Florence Lai, Patrick J. Lao, Adam Brickman, Julia Kofler, Miloš D. Ikonomović,University of California, Irvine
AAIC 2025 Abstract · 24 Dec 2025 · CC BY
Presented at AAIC 2025
