Mendelian Randomization Analyses Show an Ambiguous Association between Clonal Hematopoiesis of Indeterminate Potential and Alzheimer's Disease Risk

Abstract

Background: Clonal Hematopoiesis of Indeterminate Potential (CHIP) is a phenomenon of elevated somatic carcinogenic mutations (measured by variant allele fraction (VAF)) with a paradoxical absence of cancerous phenotypes.