Coupling between global gray matter BOLD activity and CSF movement is associated with Aβ and tau burden in preclinical Alzheimer's disease

Abstract

Background: Reduced glymphatic clearance may contribute to Alzheimer's disease. Low‐frequency CSF flow, which mediates glymphatic clearance, has tight temporal coupling (i.e., anti‐correlation) to global gray matter activity in resting‐state BOLD‐fMRI. But this coupling strength may decrease with AD.

The paper