iNOS knockout preserved brain perfusion despite MCI‐induced gut dysbiosis in an Alzheimer's mouse model

Abstract

Background: Inducible Nitric Oxide Synthase (iNOS) is implicated in exacerbating Alzheimer's Disease (AD) mechanisms. The relationship between imbalanced gut microbiota composition (dysbiosis) and AD pathology is well characterized. Many gut bacteria, including E. Coli induce iNOS production, potentially contributing to AD development.

The paper