Genetic variants in the HLA‐C gene may reduce the deleterious effect of APOE4 on Alzheimer's disease: New findings from UK Biobank

Abstract

Background: APOE4 is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD), with a higher effect in females than in males. Identifying factors that may reduce the detrimental impact of APOE4 on AD is an important research objective.