Decoding the effects of Bexarotene treatment on brain of AD‐like model mice: single‐cell transcriptomics and chromatin accessibility analysis

Abstract

Background: Bexarotene, an RXR‐specific agonist, has shown neuroprotective effects in Alzheimer's disease (AD) mouse models by improving cognition and increasing amyloid‐beta (Aβ) clearance. RXR activation regulates gene networks involved in neural development, neuroinflammation, and metabolism.

The paper