AAIC 2025 Abstract
RAB5 Hyperactivation Induces APP‐Driven Endolysosomal and Autophagic Dysfunction in Down Syndrome: Reversal by Antisense Oligonucleotides Targeting App and Rab5
Experiments in animalsInterventions
Abstract
Background: Down syndrome (DS) significantly increases the risk of Alzheimer's disease (DS‐AD), with dysfunctions in the endolysosomal network (ELN) and autophagy pathways playing central roles in its pathogenesis.
