APOE4 carriers have a unique cerebrospinal fluid and plasma proteome signature irrespective of cognitive diagnosis

Abstract

Background: Apolipoprotein E ε4 (APOE4) is the single biggest genetic risk factor for mild cognitive impairment (MCI) and sporadic Alzheimer's disease (AD). Despite this, little is known about the mechanisms underlying APOE4 carriers’ vulnerability to these diseases.

The paper