Amyloid-Tau PET Fusion Reveals Covarying Network Territories Linked to Disease Stage, Cognition, and APOE4 in Alzheimers Disease

Abstract

BackgroundAmyloid-beta (A{beta}) and Tau are defining pathologies of Alzheimers disease, but their relationship varies substantially across the brain. Amyloid deposition is spatially widespread, whereas Tau shows greater regional heterogeneity and closer relationships with disease severity.

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