Mrc Laboratory of Molecular Biology

• Ernesto Ciabatti

  Principal Investigator

Sources: gtr.ukri.org

• Engineering and Physical Sciences Research Council

  Fellowship, Development and application of Rabies Virus-based approaches for genomic editing of neural circuits in healthy and diseased brain, EP/W03672X/1, £287K, 2023–2025, Sep 1, 2023

Sources: gtr.ukri.org

• Prefrontal Planning Latency Associated With Age and Serological Evidence of Microbial Exposure

  Chronic diseases and translational medicine, Oct 27, 2026

• Share of egg cells starting to grow stays steady in aging mice

  Nature aging, Aug 13, 2026

• Reduced tubulin polyglutamylation perturbs neuronal function and causes late-onset neurodegeneration

  bioRxiv, Aug 5, 2026

• Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis

  Cell stem cell, Mar 25, 2026

• 3D Mapping of Intact Ovaries Reveals the Aging Dynamics of the Ovarian Reserve

  bioRxiv (Cold Spring Harbor Laboratory), Nov 8, 2025

• Imp, a key regulator of transposable elements, cell growth, and differentiation genes during embryogenesis

  bioRxiv (Cold Spring Harbor Laboratory), Sep 30, 2025

• Harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits

  Nature aging, May 29, 2025

• Necrosis as a fundamental driver of loss of resilience and biological decline: what if we could intervene?

  Oncogene, May 29, 2025

• Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function

  Science (New York, N.Y.), Oct 25, 2024

• Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function

  Cell, Sep 15, 2024

• The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

  Nature cell biology, Jun 21, 2024

• p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice

  Nature communications, Mar 21, 2024

• The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology

  Alzheimer's & dementia : the journal of the Alzheimer's Association, Oct 18, 2023

• Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly

  Cell reports, Aug 17, 2023

• Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation

  Nature aging, Jul 28, 2023

• Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner

  Molecular cell, Jun 23, 2023

• A Year at the Forefront of Proteostasis and Aging

  Biology open, Feb 17, 2023

• IRE-1 endoribonuclease activity declines early in C. elegans adulthood and is not rescued by reduced reproduction

  Frontiers in aging, Oct 28, 2022

• The Nuclear RNAi Pathway Regulates DAF-16/FOXO to Control C. elegans Longevity and Dauer Entry

  bioRxiv (Cold Spring Harbor Laboratory), Oct 21, 2022

• Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response

  Science immunology, May 7, 2022