Douglas Research Centre

• Sylvain Williams

  Lead investigator

• Sylvia Villeneuve

  Lead investigator

• Cherie Strikwerda-Brown

  Lead investigator

• Diane Boivin

  Lead investigator

• Pedro Rosa-Neto

  Lead investigator

Sources: openalex.org

• NCT04982211

  Phase 2, Status unknown, 150 people, Jul 29, 2021

• NCT03152175

  Phase 2, Status unknown, 64 people, May 12, 2017

• NCT03151681

  Phase 2/3, Completed, 84 people, May 12, 2017

• NCT02707458

  Phase 1/2, Completed, 23 people, Mar 14, 2016

• NCT01634347

  Phase 2, Completed, 17 people, Jul 6, 2012

• NCT01349439

  Phase 2, Status unknown, 76 people, May 6, 2011

• Gouvernement du Canada | Canadian Institutes of Health Research

  Project Grant, Revealing the role of hippocampal interneurons and principal cells in navigation and planning, 186113_1, CA$975K, 2023–2028, Jul 1, 2023

• Gouvernement du Canada | Canadian Institutes of Health Research

  Project Grant, Development and validation of blood biomarkers for the detection of preclinical Alzheimer's disease., 178385_1, CA$711K, 2021–2025, Oct 1, 2021

• Gouvernement du Canada | Canadian Institutes of Health Research

  CIHR Fellowship, Functional connectivity as a potential neural mechanism linking personality traits with risk for Alzheimer's disease, 176574_1, CA$45K, 2021–2022, Sep 1, 2021

• Gouvernement du Canada | Canadian Institutes of Health Research

  Project Grant - Priority Announcement: Neurosciences, Mental Health and Addiction, Validation of plasma amyloid-beta and tau biomarkers in the early stages of Alzheimer's disease, 173597_1, CA$100K, 2020–2021, Oct 1, 2020

• Gouvernement du Canada | Canadian Institutes of Health Research

  Project Grant, Sleep and circadian rhythms in men and women, 153080_1, CA$838K, 2017–2022, Apr 1, 2017

• Gouvernement du Canada | Canadian Institutes of Health Research

  Project Grant, Interactions between pathophysiological processes as drivers of clinical progression in Alzheimer's disease, 152985_1, CA$1.4M, 2017–2022, Apr 1, 2017

• Alzheimer's Association

  NIRG, Monitoring behavioral changes using online tools in at-risk individuals, 2016-NIRG-397028, 2016, Jan 1, 2016

Sources: openalex.org

• Cognitive-and lifestyle-related microstructural variation in the ageing human hippocampus

  Apr 23, 2025

• Beyond Hypertension: Examining Variable Blood Pressure's Role in Cognition and Brain Structure

  Sep 1, 2024

• Subjective cognitive decline is a better marker for future cognitive decline in females than in males

  Dec 29, 2022

Sources: api.crossref.org

• Current gaps in downstream applications of fMRI foundation models: lessons learned from BrainLM & BrainHarmonix on Prevent-AD

  medRxiv, Oct 26, 2026

• Spinal fluid proteins linked to Alzheimer’s markers

  Neurobiology of disease, Oct 10, 2026

• Education links to better cognition independent of brain pathology

  Alzheimer's research & therapy, Oct 4, 2026

• Higher education is linked to lower Alzheimer pathology in women

  medRxiv : the preprint server for health sciences, Oct 2, 2026

• Brain MRI predicts conversion to mild cognitive impairment

  medRxiv : the preprint server for health sciences, Oct 2, 2026

• Subjective word-finding complaints in older adults: Development and preliminary psychometric evaluation of a novel self-reported questionnaire

  medRxiv : the preprint server for health sciences, Sep 24, 2026

• Sex and Life Stage Differences in the Association Between Cognitive Engagement and Cognitive Change

  medRxiv, Sep 13, 2026

• Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer's disease

  Research square, Sep 3, 2026

• CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer's disease

  bioRxiv, Aug 27, 2026

• Linking modifiable risk factors to vascular and neurodegenerative brain changes

  GeroScience, Aug 26, 2026

• Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers

  Science advances, Aug 12, 2026

• Plasma Biomarkers for Neocortical Tau Burden

  JAMA neurology, Aug 10, 2026

• Associations between clinician-observed test anxiety and neuropsychological performance in older adults

  Applied neuropsychology. Adult, Aug 3, 2026

• Protecting the brain from post-stroke cognitive impairment and dementia with multimodal exercise training: study protocol for a Bayesian adaptive trial (PROTECT)

  BMJ open, Jul 29, 2026

• Parent-of-origin effects in Alzheimer's liability dissociate neurocognitive and cardiovascular traits in at-risk individuals

  Cell reports. Medicine, Jul 29, 2026

• A cross-sectional observational study of the psychometric properties of comprehensive health assessments of older adults in 14 African nations: The Pan-African Utilization of Lay Assessment Systems (PAULAS) Project

  Archives of gerontology and geriatrics, Jul 26, 2026

• Theoretical and practical challenges for capturing reserve and resilience in aging and Alzheimer's disease: A narrative review

  Alzheimer's & dementia : the journal of the Alzheimer's Association, Jul 25, 2026

• Cortical microstructural integrity predicts an exploitation bias in older adulthood

  The journals of gerontology. Series B, Psychological sciences and social sciences, Jul 23, 2026

• Early treatment with naproxen alters hippocampal metabolites in the TgF344-AD rat model of Alzheimer's disease

  Neurochemistry international, Jul 21, 2026

• Sex and gene variant linked to brain aging mainly with amyloid

  medRxiv, Jul 16, 2026