1:"/_next/static/immutable/chunks/0ph2n_6kgzmx9.js" 2:"/_next/static/immutable/chunks/06-jkupimj0rn.js" 3:"/_next/static/immutable/chunks/2_dyzve_7we3m.js" 4:"/_next/static/immutable/chunks/0a8k35wmt6t8c.js" 5:"/_next/static/immutable/chunks/2qcsgdoi5z-3_.js" 6:"HTTPAccessFallbackBoundary" 7:I[386861,["$1","$2","$3","$4","$5"],"$6"] 15:I[168027,["$1","$2","$3","$4","$5"],"default",1] :HL["/_next/static/immutable/chunks/0sm8-chvetc42.css","style"] :HL["/_next/static/immutable/chunks/0ab1eete86-1c.css","style"] :HL["/_next/static/immutable/media/3a11180d498b75c0-s.p.0ghexb8m2rs_v.woff2","font",{"crossOrigin":"","type":"font/woff2"}] 9:Tf70,{"@context":"https://schema.org","@graph":[{"@type":"NewsMediaOrganization","@id":"https://agingresearch.news/#organization","name":"AgingResearch.News","alternateName":["Aging Research News"],"url":"https://agingresearch.news","logo":"https://agingresearch.news/logo.png","description":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work.","slogan":"Every new aging paper, judged on evidence, never on fame.","foundingDate":"2026-10-02","parentOrganization":{"@type":"Organization","name":"Paperfoot AI Pte. Ltd.","address":{"@type":"PostalAddress","addressCountry":"SG"}},"publishingPrinciples":"https://agingresearch.news/status#standards","correctionsPolicy":"https://agingresearch.news/status#standards","ethicsPolicy":"https://agingresearch.news/status#standards","verificationFactCheckingPolicy":"https://agingresearch.news/status#standards","noBylinesPolicy":"https://agingresearch.news/status#standards","actionableFeedbackPolicy":"https://agingresearch.news/status#standards","contactPoint":{"@type":"ContactPoint","contactType":"editorial","url":"https://agingresearch.news/contact"},"knowsAbout":[{"@type":"Thing","name":"Aging","sameAs":"https://en.wikipedia.org/wiki/Ageing"},{"@type":"Thing","name":"Geroscience","sameAs":"https://en.wikipedia.org/wiki/Geroscience"},{"@type":"Thing","name":"Life extension","sameAs":"https://en.wikipedia.org/wiki/Life_extension"},{"@type":"Thing","name":"Cellular senescence","sameAs":"https://en.wikipedia.org/wiki/Cellular_senescence"},{"@type":"Thing","name":"Epigenetic clock","sameAs":"https://en.wikipedia.org/wiki/Epigenetic_clock"},{"@type":"Thing","name":"mTOR","sameAs":"https://en.wikipedia.org/wiki/MTOR"},{"@type":"Thing","name":"Rapamycin","sameAs":"https://en.wikipedia.org/wiki/Sirolimus"},{"@type":"Thing","name":"Cellular reprogramming","sameAs":"https://en.wikipedia.org/wiki/Reprogramming"},{"@type":"Thing","name":"NAD+","sameAs":"https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide"},{"@type":"Thing","name":"Sirtuins","sameAs":"https://en.wikipedia.org/wiki/Sirtuin"},{"@type":"Thing","name":"Mitochondria","sameAs":"https://en.wikipedia.org/wiki/Mitochondria"},{"@type":"Thing","name":"Calorie restriction","sameAs":"https://en.wikipedia.org/wiki/Calorie_restriction"},{"@type":"Thing","name":"GLP-1 receptor agonists","sameAs":"https://en.wikipedia.org/wiki/GLP-1_receptor_agonist"},{"@type":"Thing","name":"Inflammaging","sameAs":"https://en.wikipedia.org/wiki/Inflammaging"},{"@type":"Thing","name":"Brain aging","sameAs":"https://en.wikipedia.org/wiki/Aging_brain"},{"@type":"Thing","name":"Biological aging","sameAs":"https://en.wikipedia.org/wiki/Senescence"},{"@type":"Thing","name":"Geroprotectors","sameAs":"https://en.wikipedia.org/wiki/Geroprotector"},{"@type":"Thing","name":"Biomarkers of aging","sameAs":"https://en.wikipedia.org/wiki/Biomarkers_of_aging"},{"@type":"Thing","name":"Gerontology","sameAs":"https://en.wikipedia.org/wiki/Gerontology"},{"@type":"Thing","name":"Longevity","sameAs":"https://en.wikipedia.org/wiki/Longevity"},{"@type":"Thing","name":"Bioinformatics","sameAs":"https://en.wikipedia.org/wiki/Bioinformatics"},{"@type":"Thing","name":"Biotechnology","sameAs":"https://en.wikipedia.org/wiki/Biotechnology"},{"@type":"Thing","name":"Health policy","sameAs":"https://en.wikipedia.org/wiki/Health_policy"}],"sameAs":["https://x.com/agingbrief","https://www.linkedin.com/company/agingresearch-news"]},{"@type":"WebSite","@id":"https://agingresearch.news/#website","url":"https://agingresearch.news","name":"AgingResearch.News","alternateName":["Aging Research News"],"description":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work.","inLanguage":"en","publisher":{"@id":"https://agingresearch.news/#organization"}}]}10:X 11:[["children",{"s":"__PAGE__","d":{"r":"$L12","p":false,"v":null}}]] e:[["children",{"s":"signin","d":{"r":"$Lf","p":false,"v":"$10"},"c":"$Q11"}],["sheet",{"s":"__DEFAULT__","d":{"r":"$L13","p":false,"v":null}}]] 0:{"P":null,"c":["","signin?next=%2Fdisease%2Fcardiovascular-defect&then=wall%3Acard"],"q":"?next=%2Fdisease%2Fcardiovascular-defect&then=wall%3Acard","i":true,"t":{"t":{"s":"","h":16,"d":{"r":["$","$L7","c",{"notFound":[[["$","link","0",{"rel":"stylesheet","href":"/_next/static/immutable/chunks/0sm8-chvetc42.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}],["$","link","1",{"rel":"stylesheet","href":"/_next/static/immutable/chunks/0ab1eete86-1c.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}],["$","script","script-0",{"src":"/_next/static/immutable/chunks/0ph2n_6kgzmx9.js","async":true,"nonce":"$undefined"}],["$","script","script-1",{"src":"/_next/static/immutable/chunks/06-jkupimj0rn.js","async":true,"nonce":"$undefined"}],["$","script","script-2",{"src":"/_next/static/immutable/chunks/2_dyzve_7we3m.js","async":true,"nonce":"$undefined"}],["$","script","script-3",{"src":"/_next/static/immutable/chunks/0a8k35wmt6t8c.js","async":true,"nonce":"$undefined"}],["$","script","script-4",{"src":"/_next/static/immutable/chunks/2qcsgdoi5z-3_.js","async":true,"nonce":"$undefined"}]],["$","html",null,{"lang":"en","className":"_0coOsG_className ujwUxa_variable FJdxoa_variable Q67yJW_variable","suppressHydrationWarning":true,"children":[["$","head",null,{"children":[["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var m=localStorage.getItem(\"arn.me\");if(m)document.documentElement.dataset.me=m}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var s=sessionStorage,n=performance.getEntriesByType(\"navigation\")[0],q;try{q=JSON.parse(s.getItem(\"arn.arrivals\")||\"[]\")}catch(e){}if(!Array.isArray(q))q=[];q.push({path:location.pathname,referrer:document.referrer,search:location.search,started:s.getItem(\"arn.visit\")===\"1\",again:!!n&&(n.type===\"reload\"||n.type===\"back_forward\")});s.setItem(\"arn.arrivals\",JSON.stringify(q.slice(-20)));s.setItem(\"arn.visit\",\"1\")}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var d=document.documentElement,o=false,s=null;try{s=sessionStorage;o=s.getItem(\"arn.offers\")===\"off\"}catch(e){}if(!o){var u=(new URLSearchParams(location.search).get(\"utm_source\")||\"\").trim().toLowerCase(),h=\"\";try{h=new URL(document.referrer).hostname.toLowerCase().replace(/^www\\./,\"\")}catch(e){}o=[\"chatgpt\",\"chatgpt.com\",\"chat.openai.com\"].indexOf(u)>=0||[\"chatgpt.com\",\"chat.openai.com\",\"oaiusercontent.com\"].some(function(x){return h===x||h.slice(-x.length-1)===\".\"+x});if(o&&s)try{s.setItem(\"arn.offers\",\"off\")}catch(e){}}if(o)d.dataset.offers=\"off\"}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var v=(new URLSearchParams(location.search).get(\"via\")||\"\").trim().toLowerCase();if(/^(?:[a-z]{1,12}-)?[a-z0-9]{8}$/.test(v))document.documentElement.dataset.joinOff=location.pathname}catch(e){}"}}],"$L8"]}],["$","body",null,{"className":"min-h-dvh bg-paper font-sans text-ink","children":[["$","a",null,{"href":"#content","className":"skip-link","children":"Skip to content"}],["$","script",null,{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"$9"}}],"$La","$Lb","$Lc"]}]]}]],"children":["$0:t:t:d:r:props:notFound:0","$Ld"]}],"p":false,"v":null},"c":"$Qe"},"h":{"r":"$L14","p":false,"v":null}},"m":"$undefined","G":["$15",["$L16","$L17"]],"S":false,"r":"$undefined","s":"$undefined","a":"$undefined","l":"$undefined","p":"$undefined","d":"$undefined"} 18:I[684230,["$1","$2","$3","$4","$5"],"MeProvider"] 19:"/_next/static/immutable/chunks/1tymo652zl28i.js" 1a:"/_next/static/immutable/chunks/3jf1exf-pxi47.js" 1b:"/_next/static/immutable/chunks/0fa6wzndmlaos.js" 1c:"/_next/static/immutable/chunks/073w6i91dnqty.js" 1d:I[432748,["$1","$2","$3","$4","$5","$19","$1a","$1b","$1c"],"Unplaced"] 1e:"/_next/static/immutable/chunks/1k_0n34m_77mm.js" 1f:I[675689,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"Rail"] 20:I[435939,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"SiteHeader"] 21:I[779780,["$1","$2","$3","$4","$5","$19","$1a","$1b","$1c"],"SearchIcon"] 22:I[522016,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],""] 2b:I[124213,["$1","$2","$3","$4","$5"],"PageviewBeacon"] 2c:I[401529,["$1","$2","$3","$4","$5"],"VitalsBeacon"] 32:"$Sreact.fragment" 33:I[339756,["$1","$2","$3","$4","$5"],"default"] 34:I[837457,["$1","$2","$3","$4","$5"],"default"] 36:I[897367,["$1","$2","$3","$4","$5"],"OutletBoundary"] 38:"ViewportBoundary" 39:I[897367,["$1","$2","$3","$4","$5"],"$38"] 3b:"MetadataBoundary" 3c:I[897367,["$1","$2","$3","$4","$5"],"$3b"] 3d:"$Sreact.suspense" a:["$","$L18",null,{"children":[[[],[["$","$L1d",null,{"children":["$","div",null,{"className":"frame","data-wide":"$undefined","children":[["$","$L1f",null,{"hint":"$undefined","updatesAt":"2026-10-16T23:45:00+01:00"}],["$","div",null,{"className":"frame-column min-w-0","children":[[["$","$L20",null,{"hint":"$undefined"}],["$","div",null,{"id":"content","tabIndex":-1,"className":"outline-none"}]],["$","main",null,{"className":"min-w-0 px-(--col-pad) lg:pb-16 pt-4 md:pt-5","children":[["$","header",null,{"className":"bleed flex items-end justify-between gap-6 border-b border-rule px-(--col-pad) pb-3","children":[["$","div",null,{"className":"min-w-0","children":["$undefined",["$","h1",null,{"className":"headline text-[22px] leading-[1.15] font-extrabold tracking-[-0.02em] text-ink","children":"Page not found"}],"$undefined"]}],"$undefined"]}],["$","p",null,{"className":"mt-4 text-[15px] leading-[1.4] text-pretty text-ink-soft","children":"The link may be old or mistyped."}],["$","form",null,{"action":"/search","method":"get","role":"search","aria-label":"Site","className":"relative mt-6 lg:hidden","children":[["$","span",null,{"aria-hidden":true,"className":"pointer-events-none absolute top-1/2 left-3.5 -translate-y-1/2 text-muted","children":["$","$L21",null,{"className":"size-[20px]"}]}],["$","input",null,{"name":"q","type":"search","inputMode":"search","enterKeyHint":"search","autoComplete":"off","autoCorrect":"off","autoCapitalize":"none","spellCheck":false,"maxLength":200,"placeholder":"Search papers, drugs, genes","aria-label":"Search aging research","className":"h-11 w-full appearance-none rounded-lg border-[1.5px] border-transparent bg-paper-deep pr-4 pl-11 text-[16px] text-ink transition-colors duration-[120ms] outline-none placeholder:text-muted focus:border-ink focus:bg-paper"}]]}],["$","ul",null,{"className":"mt-6","children":[["$","li","/",{"children":["$","$L22",null,{"href":"/","prefetch":false,"className":"bleed flex min-h-12 items-center border-b border-rule px-(--col-pad) text-[15px] font-bold transition-colors duration-[120ms] hover:bg-hover active:bg-pressed","children":"Home"}]}],["$","li","/latest",{"children":["$","$L22",null,{"href":"/latest","prefetch":false,"className":"bleed flex min-h-12 items-center border-b border-rule px-(--col-pad) text-[15px] font-bold transition-colors duration-[120ms] hover:bg-hover active:bg-pressed","children":"Latest"}]}],["$","li","/topics",{"children":["$","$L22",null,{"href":"/topics","prefetch":false,"className":"bleed flex min-h-12 items-center border-b border-rule px-(--col-pad) text-[15px] font-bold transition-colors duration-[120ms] hover:bg-hover active:bg-pressed","children":"Topics"}]}]]}]]}],["$","footer",null,{"className":"mt-16 border-t border-rule sm:mt-20 lg:hidden","children":["$","nav",null,{"aria-label":"Footer","className":"flex flex-wrap items-center gap-x-3.5 px-4 py-2 text-[13px] text-muted","children":[[["$","$L22","/connect",{"href":"/connect","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"AI assistants"}],["$","$L22","/privacy",{"href":"/privacy","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"Privacy"}],["$","$L22","/terms",{"href":"/terms","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"Terms"}],["$","$L22","/contact",{"href":"/contact","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"Contact"}],["$","$L22","/feeds",{"href":"/feeds","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"RSS"}]],["$","a",null,{"href":"https://x.com/agingbrief","target":"_blank","rel":"noopener","title":"Follow @agingbrief on X","className":"inline-flex items-center gap-1.5 min-h-11 transition-colors duration-[120ms] hover:text-ink","children":[["$","svg",null,{"viewBox":"0 0 1200 1227","aria-hidden":true,"className":"shrink-0 size-[11px]","fill":"currentColor","children":["$","path",null,{"d":"M714.163 519.284L1160.89 0H1055.03L667.137 450.887L357.328 0H0L468.492 681.821L0 1226.37H105.866L515.491 750.218L842.672 1226.37H1200L714.137 519.284H714.163ZM569.165 687.828L521.697 619.934L144.011 79.6944H306.615L611.412 515.685L658.88 583.579L1055.08 1150.3H892.476L569.165 687.854V687.828Z"}]}],"Follow on X"]}],"$L23"]}]}],"$L24"]}],"$L25","$L26"]}]}],"$a:props:children:0:0"]],"$undefined","$L27","$L28","$L29","$L2a"]}] b:["$","$L2b",null,{}] c:["$","$L2c",null,{}] 2e:Tf70,{"@context":"https://schema.org","@graph":[{"@type":"NewsMediaOrganization","@id":"https://agingresearch.news/#organization","name":"AgingResearch.News","alternateName":["Aging Research News"],"url":"https://agingresearch.news","logo":"https://agingresearch.news/logo.png","description":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work.","slogan":"Every new aging paper, judged on evidence, never on fame.","foundingDate":"2026-10-02","parentOrganization":{"@type":"Organization","name":"Paperfoot AI Pte. Ltd.","address":{"@type":"PostalAddress","addressCountry":"SG"}},"publishingPrinciples":"https://agingresearch.news/status#standards","correctionsPolicy":"https://agingresearch.news/status#standards","ethicsPolicy":"https://agingresearch.news/status#standards","verificationFactCheckingPolicy":"https://agingresearch.news/status#standards","noBylinesPolicy":"https://agingresearch.news/status#standards","actionableFeedbackPolicy":"https://agingresearch.news/status#standards","contactPoint":{"@type":"ContactPoint","contactType":"editorial","url":"https://agingresearch.news/contact"},"knowsAbout":[{"@type":"Thing","name":"Aging","sameAs":"https://en.wikipedia.org/wiki/Ageing"},{"@type":"Thing","name":"Geroscience","sameAs":"https://en.wikipedia.org/wiki/Geroscience"},{"@type":"Thing","name":"Life extension","sameAs":"https://en.wikipedia.org/wiki/Life_extension"},{"@type":"Thing","name":"Cellular senescence","sameAs":"https://en.wikipedia.org/wiki/Cellular_senescence"},{"@type":"Thing","name":"Epigenetic clock","sameAs":"https://en.wikipedia.org/wiki/Epigenetic_clock"},{"@type":"Thing","name":"mTOR","sameAs":"https://en.wikipedia.org/wiki/MTOR"},{"@type":"Thing","name":"Rapamycin","sameAs":"https://en.wikipedia.org/wiki/Sirolimus"},{"@type":"Thing","name":"Cellular reprogramming","sameAs":"https://en.wikipedia.org/wiki/Reprogramming"},{"@type":"Thing","name":"NAD+","sameAs":"https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide"},{"@type":"Thing","name":"Sirtuins","sameAs":"https://en.wikipedia.org/wiki/Sirtuin"},{"@type":"Thing","name":"Mitochondria","sameAs":"https://en.wikipedia.org/wiki/Mitochondria"},{"@type":"Thing","name":"Calorie restriction","sameAs":"https://en.wikipedia.org/wiki/Calorie_restriction"},{"@type":"Thing","name":"GLP-1 receptor agonists","sameAs":"https://en.wikipedia.org/wiki/GLP-1_receptor_agonist"},{"@type":"Thing","name":"Inflammaging","sameAs":"https://en.wikipedia.org/wiki/Inflammaging"},{"@type":"Thing","name":"Brain aging","sameAs":"https://en.wikipedia.org/wiki/Aging_brain"},{"@type":"Thing","name":"Biological aging","sameAs":"https://en.wikipedia.org/wiki/Senescence"},{"@type":"Thing","name":"Geroprotectors","sameAs":"https://en.wikipedia.org/wiki/Geroprotector"},{"@type":"Thing","name":"Biomarkers of aging","sameAs":"https://en.wikipedia.org/wiki/Biomarkers_of_aging"},{"@type":"Thing","name":"Gerontology","sameAs":"https://en.wikipedia.org/wiki/Gerontology"},{"@type":"Thing","name":"Longevity","sameAs":"https://en.wikipedia.org/wiki/Longevity"},{"@type":"Thing","name":"Bioinformatics","sameAs":"https://en.wikipedia.org/wiki/Bioinformatics"},{"@type":"Thing","name":"Biotechnology","sameAs":"https://en.wikipedia.org/wiki/Biotechnology"},{"@type":"Thing","name":"Health policy","sameAs":"https://en.wikipedia.org/wiki/Health_policy"}],"sameAs":["https://x.com/agingbrief","https://www.linkedin.com/company/agingresearch-news"]},{"@type":"WebSite","@id":"https://agingresearch.news/#website","url":"https://agingresearch.news","name":"AgingResearch.News","alternateName":["Aging Research News"],"description":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work.","inLanguage":"en","publisher":{"@id":"https://agingresearch.news/#organization"}}]}d:["$","html",null,{"lang":"en","className":"_0coOsG_className ujwUxa_variable FJdxoa_variable Q67yJW_variable","suppressHydrationWarning":true,"children":[["$","head",null,{"children":[["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var m=localStorage.getItem(\"arn.me\");if(m)document.documentElement.dataset.me=m}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var s=sessionStorage,n=performance.getEntriesByType(\"navigation\")[0],q;try{q=JSON.parse(s.getItem(\"arn.arrivals\")||\"[]\")}catch(e){}if(!Array.isArray(q))q=[];q.push({path:location.pathname,referrer:document.referrer,search:location.search,started:s.getItem(\"arn.visit\")===\"1\",again:!!n&&(n.type===\"reload\"||n.type===\"back_forward\")});s.setItem(\"arn.arrivals\",JSON.stringify(q.slice(-20)));s.setItem(\"arn.visit\",\"1\")}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var d=document.documentElement,o=false,s=null;try{s=sessionStorage;o=s.getItem(\"arn.offers\")===\"off\"}catch(e){}if(!o){var u=(new URLSearchParams(location.search).get(\"utm_source\")||\"\").trim().toLowerCase(),h=\"\";try{h=new URL(document.referrer).hostname.toLowerCase().replace(/^www\\./,\"\")}catch(e){}o=[\"chatgpt\",\"chatgpt.com\",\"chat.openai.com\"].indexOf(u)>=0||[\"chatgpt.com\",\"chat.openai.com\",\"oaiusercontent.com\"].some(function(x){return h===x||h.slice(-x.length-1)===\".\"+x});if(o&&s)try{s.setItem(\"arn.offers\",\"off\")}catch(e){}}if(o)d.dataset.offers=\"off\"}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var v=(new URLSearchParams(location.search).get(\"via\")||\"\").trim().toLowerCase();if(/^(?:[a-z]{1,12}-)?[a-z0-9]{8}$/.test(v))document.documentElement.dataset.joinOff=location.pathname}catch(e){}"}}],"$L2d"]}],["$","body",null,{"className":"min-h-dvh bg-paper font-sans text-ink","children":[["$","a",null,{"href":"#content","className":"skip-link","children":"Skip to content"}],["$","script",null,{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"$2e"}}],"$L2f","$L30","$L31"]}]]}] f:["$","$32","c",{"children":[null,["$","$L33",null,{"parallelRouterKey":"children","error":"$undefined","errorStyles":"$undefined","errorScripts":"$undefined","template":["$","$L34",null,{}],"templateStyles":"$undefined","templateScripts":"$undefined","notFound":"$undefined","forbidden":"$undefined","unauthorized":"$undefined"}]]}] 12:["$","$32","c",{"children":["$L35",[["$","script","script-0",{"src":"/_next/static/immutable/chunks/1k_0n34m_77mm.js","async":true,"nonce":"$undefined"}],["$","script","script-1",{"src":"/_next/static/immutable/chunks/1tymo652zl28i.js","async":true,"nonce":"$undefined"}],["$","script","script-2",{"src":"/_next/static/immutable/chunks/0fa6wzndmlaos.js","async":true,"nonce":"$undefined"}],["$","script","script-3",{"src":"/_next/static/immutable/chunks/073w6i91dnqty.js","async":true,"nonce":"$undefined"}],["$","script","script-4",{"src":"/_next/static/immutable/chunks/3jf1exf-pxi47.js","async":true,"nonce":"$undefined"}]],["$","$L36",null,{"children":"$@37"}]]}] 13:["$","$32","c",{"children":[null,null,null]}] 14:["$","$32","h",{"children":[null,["$","$L39",null,{"children":"$L3a"}],["$","$L3c",null,{"children":[["$","div",null,{"hidden":true,"children":["$","$3d",null,{"name":"Next.Metadata","children":"$L3e"}]}],"$L3f"]}],["$","meta",null,{"name":"next-size-adjust","content":""}]]}] 16:["$","link","0",{"rel":"stylesheet","href":"/_next/static/immutable/chunks/0sm8-chvetc42.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}] 17:["$","link","1",{"rel":"stylesheet","href":"/_next/static/immutable/chunks/0ab1eete86-1c.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}] 40:I[149277,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"FoundingBar"] 41:I[36861,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"SharedBy"] 42:I[936821,["$1","$2","$3","$4","$5"],"AuthHost"] 43:I[188415,["$1","$2","$3","$4","$5"],"BottomTabBar"] 44:I[233785,["$1","$2","$3","$4","$5"],"FeedTracker"] 45:I[696255,["$1","$2","$3","$4","$5"],"NavMemory"] 46:"/_next/static/immutable/chunks/1a87oerwdbo4c.js" 47:I[408821,["$1","$2","$3","$4","$5","$46"],"default"] 10:C 23:["$","span",null,{"children":["© ",2026," AgingResearch.News"]}] 24:["$","$L40",null,{"until":"2026-11-30T23:59:59.000Z"}] 25:["$","$L41",null,{}] 27:["$","$L42",null,{"oneTapClientId":"1014590465548-acrir82hrkhsm9kpku98fp77435bh7qo.apps.googleusercontent.com"}] 28:["$","$L43",null,{}] 29:["$","$L44",null,{}] 2a:["$","$L45",null,{}] 2f:["$","$L18",null,{"children":[["$","$L33",null,{"parallelRouterKey":"children","error":"$47","errorStyles":[],"errorScripts":[["$","script","script-0",{"src":"/_next/static/immutable/chunks/1a87oerwdbo4c.js","async":true,"nonce":"$undefined"}]],"template":["$","$L34",null,{}],"templateStyles":"$undefined","templateScripts":"$undefined","notFound":"$a:props:children:0:1","forbidden":"$undefined","unauthorized":"$undefined"}],["$","$L33",null,{"parallelRouterKey":"sheet","error":"$47","errorStyles":"$2f:props:children:0:props:errorStyles","errorScripts":"$2f:props:children:0:props:errorScripts","template":["$","$L34",null,{}],"templateStyles":"$undefined","templateScripts":"$undefined","notFound":"$undefined","forbidden":"$undefined","unauthorized":"$undefined"}],["$","$L42",null,{"oneTapClientId":"1014590465548-acrir82hrkhsm9kpku98fp77435bh7qo.apps.googleusercontent.com"}],["$","$L43",null,{}],["$","$L44",null,{}],["$","$L45",null,{}]]}] 30:["$","$L2b",null,{}] 31:["$","$L2c",null,{}] 3a:[["$","meta","0",{"charSet":"utf-8"}],["$","meta","1",{"name":"viewport","content":"width=device-width, initial-scale=1, viewport-fit=cover"}],["$","meta","2",{"name":"theme-color","content":"#ffffff","media":"(prefers-color-scheme: light)"}],["$","meta","3",{"name":"theme-color","content":"#242424","media":"(prefers-color-scheme: dark)"}],["$","meta","4",{"name":"color-scheme","content":"light dark"}]] 48:I[27201,["$1","$2","$3","$4","$5"],"IconMark"] 37:null 3e:[["$","title","0",{"children":"Sign in · AgingResearch.News"}],["$","meta","1",{"name":"description","content":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work."}],["$","meta","2",{"name":"application-name","content":"AgingResearch.News"}],["$","link","3",{"rel":"author","href":"https://agingresearch.news"}],["$","meta","4",{"name":"author","content":"AgingResearch.News"}],["$","link","5",{"rel":"manifest","href":"/manifest.webmanifest","crossOrigin":"$undefined"}],["$","meta","6",{"name":"keywords","content":"superintelligence for aging research,aging research superintelligence,longevity superintelligence,aging research,longevity research,geroscience,longevity medicine,biomarkers of aging,aging clinical trials,AI in aging research,cellular senescence,senolytics,epigenetic clocks,rapamycin,partial reprogramming,NAD+"}],["$","meta","7",{"name":"creator","content":"AgingResearch.News"}],["$","meta","8",{"name":"publisher","content":"AgingResearch.News"}],["$","meta","9",{"name":"robots","content":"noindex"}],["$","meta","10",{"name":"category","content":"science"}],["$","link","11",{"rel":"alternate","type":"application/rss+xml","href":"https://agingresearch.news/feed.xml","title":"AgingResearch.News: latest stories"}],["$","meta","12",{"name":"format-detection","content":"telephone=no, address=no, email=no"}],["$","meta","13",{"property":"og:title","content":"Sign in · AgingResearch.News"}],["$","meta","14",{"property":"og:description","content":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work."}],["$","meta","15",{"property":"og:site_name","content":"AgingResearch.News"}],["$","meta","16",{"property":"og:locale","content":"en_GB"}],["$","meta","17",{"property":"og:image","content":"https://agingresearch.news/og/site/home/card.jpg"}],["$","meta","18",{"property":"og:image:type","content":"image/jpeg"}],["$","meta","19",{"property":"og:image:width","content":"1200"}],["$","meta","20",{"property":"og:image:height","content":"630"}],["$","meta","21",{"property":"og:image:alt","content":"AgingResearch.News: every new aging paper, judged on evidence, never on fame."}],["$","meta","22",{"property":"og:type","content":"website"}],["$","meta","23",{"name":"twitter:card","content":"summary_large_image"}],["$","meta","24",{"name":"twitter:site","content":"@agingbrief"}],["$","meta","25",{"name":"twitter:creator","content":"@agingbrief"}],["$","meta","26",{"name":"twitter:title","content":"Sign in · AgingResearch.News"}],["$","meta","27",{"name":"twitter:description","content":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work."}],["$","meta","28",{"name":"twitter:image","content":"https://agingresearch.news/og/site/home/card.jpg"}],["$","meta","29",{"name":"twitter:image:alt","content":"AgingResearch.News: every new aging paper, judged on evidence, never on fame."}],["$","meta","30",{"name":"twitter:image:type","content":"image/jpeg"}],["$","meta","31",{"name":"twitter:image:width","content":"1200"}],["$","meta","32",{"name":"twitter:image:height","content":"630"}],["$","link","33",{"rel":"icon","href":"/favicon.ico?favicon.2k_45p2z8od_f.ico","sizes":"48x48","type":"image/x-icon"}],["$","link","34",{"rel":"icon","href":"/icon.svg","type":"image/svg+xml","sizes":"any"}],["$","link","35",{"rel":"apple-touch-icon","href":"/apple-touch-icon.png"}],["$","$L48","36",{}]] 3f:null 49:I[259435,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"SignInPageMark"] 4a:I[79485,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"Continue"] 35:["$","div",null,{"className":"frame","data-wide":"$undefined","children":[["$","$L1f",null,{"hint":"$undefined","updatesAt":"2026-10-16T23:45:00+01:00"}],["$","div",null,{"className":"frame-column min-w-0","children":[[["$","$L20",null,{"hint":"$undefined"}],["$","div",null,{"id":"content","tabIndex":-1,"className":"outline-none"}]],["$","main",null,{"className":"min-w-0 px-(--col-pad) lg:pb-16 pt-8 sm:pt-14","children":[["$","$L49",null,{}],["$","div",null,{"className":"mx-auto max-w-[400px] pb-12 Q67yJW_variable","children":["$","$L4a",null,{"checkout":null,"connecting":null,"plain":false,"methods":{"google":true,"apple":true,"x":true,"phone":false,"microsoft":false},"botCheckKey":null,"lastUsed":null,"lastSso":null,"accessThrough":null,"next":"/disease/cardiovascular-defect","then":"wall:card","notice":null,"email":null,"trialDays":14}]}]]}],["$","footer",null,{"className":"mt-16 border-t border-rule sm:mt-20 lg:hidden","children":["$","nav",null,{"aria-label":"Footer","className":"flex flex-wrap items-center gap-x-3.5 px-4 py-2 text-[13px] text-muted","children":[[["$","$L22","/connect",{"href":"/connect","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"AI assistants"}],["$","$L22","/privacy",{"href":"/privacy","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"Privacy"}],["$","$L22","/terms",{"href":"/terms","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"Terms"}],["$","$L22","/contact",{"href":"/contact","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"Contact"}],["$","$L22","/feeds",{"href":"/feeds","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":"RSS"}]],["$","a",null,{"href":"https://x.com/agingbrief","target":"_blank","rel":"noopener","title":"Follow @agingbrief on X","className":"inline-flex items-center gap-1.5 min-h-11 transition-colors duration-[120ms] hover:text-ink","children":[["$","svg",null,{"viewBox":"0 0 1200 1227","aria-hidden":true,"className":"shrink-0 size-[11px]","fill":"currentColor","children":["$","path",null,{"d":"M714.163 519.284L1160.89 0H1055.03L667.137 450.887L357.328 0H0L468.492 681.821L0 1226.37H105.866L515.491 750.218L842.672 1226.37H1200L714.137 519.284H714.163ZM569.165 687.828L521.697 619.934L144.011 79.6944H306.615L611.412 515.685L658.88 583.579L1055.08 1150.3H892.476L569.165 687.854V687.828Z"}]}],"Follow on X"]}],["$","span",null,{"children":["© ",2026," AgingResearch.News"]}]]}]}],["$","$L40",null,{"until":"2026-11-30T23:59:59.000Z"}]]}],["$","$L41",null,{}],"$L4b"]}] 4c:I[545892,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"SidebarSearch"] 4d:I[43816,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"StickyRail"] 4e:I[27054,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"JoinCard"] 4f:I[892174,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"HideOn"] 50:I[605500,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"Image"] 51:I[743237,["$1","$2","$3","$4","$5","$1e","$19","$1b","$1c","$1a"],"IntentLink"] 26:["$","aside",null,{"aria-label":"Sidebar","className":"sidebar hidden lg:block","children":[["$","$L4c",null,{}],["$","$L4d",null,{"className":"space-y-3.5 pt-2 pb-10","children":[["$","$L4e",null,{"methods":{"google":true,"apple":true},"trialDays":14}],["$","$L4f",null,{"section":"/news","children":["$","section",null,{"aria-labelledby":"rail-news","className":"module","children":[["$","div",null,{"className":"module-head","children":[["$","h2",null,{"id":"rail-news","className":"module-title","children":"News"}],["$","$L22",null,{"href":"/news","aria-label":"See all news","className":"module-more","children":"See all"}]]}],[["$","a","522",{"href":"https://www.fightaging.org/archives/2026/10/epigenetic-aging-is-accelerated-in-large-dogs-versus-small-dogs/","target":"_blank","rel":"noopener","className":"module-row grid grid-cols-[minmax(0,1fr)_auto] items-start gap-3","children":[["$","span",null,{"className":"min-w-0","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Large dogs show 31% stronger age-related methylation loss at transposable elements"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":[["$","span",null,{"title":"$undefined","className":"tag","children":"Research"}],["$","span",null,{"className":"min-w-0","children":"Fight Aging! and 6 more"}]]}]]}],["$","$L50",null,{"src":"/fig/news-3367/062b064f.webp","alt":"","width":48,"height":48,"sizes":"48px","loading":"lazy","draggable":false,"className":"size-12 rounded-lg bg-paper-deep object-cover"}]]}],["$","a","1233",{"href":"https://medicalxpress.com/news/2026-10-ovaries-decades-menopause-reveals.html","target":"_blank","rel":"noopener","className":"module-row grid grid-cols-[minmax(0,1fr)_auto] items-start gap-3","children":[["$","span",null,{"className":"min-w-0","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Human ovaries keep remodeling with increasing inflammation decades after menopause, researchers report"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":[["$","span",null,{"title":"$undefined","className":"tag","children":"Research"}],["$","span",null,{"className":"min-w-0","children":"Medical Xpress and 5 more"}]]}]]}],["$","$L50",null,{"src":"/fig/news-6288/87ff257e.webp","alt":"","width":48,"height":48,"sizes":"48px","loading":"lazy","draggable":false,"className":"size-12 rounded-lg bg-paper-deep object-cover"}]]}],["$","a","1412",{"href":"https://lifespan.io/blocking-sting-helps-preserve-bone-in-aging-mice/","target":"_blank","rel":"noopener","className":"module-row grid grid-cols-[minmax(0,1fr)_auto] items-start gap-3","children":[["$","span",null,{"className":"min-w-0","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Researchers report STING blockade limits bone loss in aging mice"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":[["$","span",null,{"title":"$undefined","className":"tag","children":"Research"}],["$","span",null,{"className":"min-w-0","children":"Lifespan.io and 2 more"}]]}]]}],["$","$L50",null,{"src":"/fig/news-9012/8dad66bd.webp","alt":"","width":48,"height":48,"sizes":"48px","loading":"lazy","draggable":false,"className":"size-12 rounded-lg bg-paper-deep object-cover"}]]}]]]}]}],["$","$L4f",null,{"section":"/trials","children":["$","section",null,{"aria-labelledby":"rail-trials","className":"module","children":[["$","div",null,{"className":"module-head","children":[["$","h2",null,{"id":"rail-trials","className":"module-title","children":"Trials"}],["$","$L22",null,{"href":"/trials","aria-label":"See all trials","className":"module-more","children":"See all"}]]}],[["$","$L51","NCT03888040",{"href":"/trials/NCT03888040","className":"module-row","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":["","$L52"]}]]}],"$L53","$L54"]]}]}],"$L55","$L56","$L57"]}]]}] 4b:["$","aside",null,{"aria-label":"Sidebar","className":"sidebar hidden lg:block","children":[["$","$L4c",null,{}],["$","$L4d",null,{"className":"space-y-3.5 pt-2 pb-10","children":[["$","$L4e",null,{"methods":{"google":true,"apple":true},"trialDays":14}],["$","$L4f",null,{"section":"/news","children":["$","section",null,{"aria-labelledby":"rail-news","className":"module","children":[["$","div",null,{"className":"module-head","children":[["$","h2",null,{"id":"rail-news","className":"module-title","children":"News"}],["$","$L22",null,{"href":"/news","aria-label":"See all news","className":"module-more","children":"See all"}]]}],[["$","a","522",{"href":"https://www.fightaging.org/archives/2026/10/epigenetic-aging-is-accelerated-in-large-dogs-versus-small-dogs/","target":"_blank","rel":"noopener","className":"module-row grid grid-cols-[minmax(0,1fr)_auto] items-start gap-3","children":[["$","span",null,{"className":"min-w-0","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Large dogs show 31% stronger age-related methylation loss at transposable elements"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":[["$","span",null,{"title":"$undefined","className":"tag","children":"Research"}],["$","span",null,{"className":"min-w-0","children":"Fight Aging! and 6 more"}]]}]]}],["$","$L50",null,{"src":"/fig/news-3367/062b064f.webp","alt":"","width":48,"height":48,"sizes":"48px","loading":"lazy","draggable":false,"className":"size-12 rounded-lg bg-paper-deep object-cover"}]]}],["$","a","1233",{"href":"https://medicalxpress.com/news/2026-10-ovaries-decades-menopause-reveals.html","target":"_blank","rel":"noopener","className":"module-row grid grid-cols-[minmax(0,1fr)_auto] items-start gap-3","children":[["$","span",null,{"className":"min-w-0","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Human ovaries keep remodeling with increasing inflammation decades after menopause, researchers report"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":[["$","span",null,{"title":"$undefined","className":"tag","children":"Research"}],["$","span",null,{"className":"min-w-0","children":"Medical Xpress and 5 more"}]]}]]}],["$","$L50",null,{"src":"/fig/news-6288/87ff257e.webp","alt":"","width":48,"height":48,"sizes":"48px","loading":"lazy","draggable":false,"className":"size-12 rounded-lg bg-paper-deep object-cover"}]]}],["$","a","1412",{"href":"https://lifespan.io/blocking-sting-helps-preserve-bone-in-aging-mice/","target":"_blank","rel":"noopener","className":"module-row grid grid-cols-[minmax(0,1fr)_auto] items-start gap-3","children":[["$","span",null,{"className":"min-w-0","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Researchers report STING blockade limits bone loss in aging mice"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":[["$","span",null,{"title":"$undefined","className":"tag","children":"Research"}],["$","span",null,{"className":"min-w-0","children":"Lifespan.io and 2 more"}]]}]]}],["$","$L50",null,{"src":"/fig/news-9012/8dad66bd.webp","alt":"","width":48,"height":48,"sizes":"48px","loading":"lazy","draggable":false,"className":"size-12 rounded-lg bg-paper-deep object-cover"}]]}]]]}]}],["$","$L4f",null,{"section":"/trials","children":["$","section",null,{"aria-labelledby":"rail-trials","className":"module","children":[["$","div",null,{"className":"module-head","children":[["$","h2",null,{"id":"rail-trials","className":"module-title","children":"Trials"}],["$","$L22",null,{"href":"/trials","aria-label":"See all trials","className":"module-more","children":"See all"}]]}],[["$","$L51","NCT03888040",{"href":"/trials/NCT03888040","className":"module-row","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":["","$L58"]}]]}],"$L59","$L5a"]]}]}],"$L5b","$L5c","$L5d"]}]]}] 5e:T5d5,(function(c){try{var d=document.documentElement,i,j,K=/^[a-z0-9-]{1,40}$/,own=function(o,k){return Object.prototype.hasOwnProperty.call(o,k)};for(i=0;i

Join AgingResearch.News, free