Vitrified partial heart transplantation

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

Pulmonary valve annulus growth

no changein pigs1

1 study

Vitrified partial heart transplantation has no effect on pulmonary valve annulus growth in pigs (Difference in slopes = -0.005 [-0.010, 0.000] cm/day, p = 0.065).
“The vitrified PHT cohort showed steady valvular growth (Slope = 0.003 [-0.000, 0.006] cm/day, p = 0.095), matching fresh PHT (Difference in slopes = -0.005 [-0.010, 0.000] cm/day, p = 0.065)”
Animalsorthotopically transplanted into wildtype recipient pigletspulmonary valveuntil recipients had doubled in weight
Vitrified Partial Heart Transplants Grow at the Same Rate as Fresh Partial Heart Transplants and Retain Viable Donor Cells In-Vivo
AHA Scientific Sessions 2025 abstract3 Nov 2025

Pulmonary valve gradient growth

no changein pigs1

1 study

Vitrified partial heart transplantation has no effect on pulmonary valve gradient growth in pigs (Difference in slopes = 0.225 [-0.070, 0.521] mmHg/day, p = 0.166).
“There is no statistically significant difference in the post-operative growth of gradient for vitrified cohort (Slope = 0.262 [0.113, 0.411] mmHg/day, p < 0.001) compared to fresh PHT cohort”
Animalsorthotopically transplanted into wildtype recipient pigletspulmonary valveuntil recipients had doubled in weight
Vitrified Partial Heart Transplants Grow at the Same Rate as Fresh Partial Heart Transplants and Retain Viable Donor Cells In-Vivo
AHA Scientific Sessions 2025 abstract3 Nov 2025

Latest

1 in 12 months

AHA Scientific Sessions 2025 Abstract3 Nov

Vitrified Partial Heart Transplants Grow at the Same Rate as Fresh Partial Heart Transplants and Retain Viable Donor Cells In-Vivo

Experiments in pigsInterventions

Paper

Vitrified partial heart transplantation

Outcomes

Latest

Vitrified Partial Heart Transplants Grow at the Same Rate as Fresh Partial Heart Transplants and Retain Viable Donor Cells In-Vivo

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