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TOP-N53

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institutes of Health and 3 more
  • 2 of 2 findings with company ties
  • Model organisms1

Outcomes

2

Healthspan

upin worms1

1 study

  1. TOP-N53 improves healthspan in worms.

    “TOP-N53, a dual-acting NO donor and PDE5 inhibitor, can increase both lifespan and health span in C. elegans”

    Model organisms

    Dual-Acting Nitric Oxide Donor and Phosphodiesterase Inhibitor TOP-N53 Increases Lifespan and Health Span of Caenorhabditis elegans

    microPublication biologyApr 10, 2024

Lifespan

upin worms1

1 study

  1. TOP-N53 extends lifespan in worms.

    “TOP-N53, a dual-acting NO donor and PDE5 inhibitor, can increase both lifespan and health span in C. elegans”

    Model organisms

    Dual-Acting Nitric Oxide Donor and Phosphodiesterase Inhibitor TOP-N53 Increases Lifespan and Health Span of Caenorhabditis elegans

    microPublication biologyApr 10, 2024

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