Tokishakuyakusan
Intervention1 paper6 findings
In one rat study of advanced maternal age, a 3% tokishakuyakusan diet for four weeks reduces pregnancy loss and increases the live foetus rate and placental efficiency. It also increases plasma progesterone and placental FLT1 while reducing plasma inflammation.
- Animals1
Outcomes
6FLT1
upin rats1Very low certainty
1 study
FLT1
upin rats1Very low certainty
Tokishakuyakusan increases FLT1 in rats.
Animalsadvanced maternal agediet containing 3% tokishakuyakusanplacenta3%4 weeksfemales
Tokishakuyakusan ameliorates age-related pregnancy loss by modulating endocrine, inflammatory, and placental factors in an advanced maternal age rat model · Journal of ethnopharmacology · 22 Sep 2026
Inflammation
downin rats1Very low certainty
1 study
Inflammation
downin rats1Very low certainty
Tokishakuyakusan decreases inflammation in rats.
Animalsadvanced maternal agediet containing 3% tokishakuyakusanplasma3%4 weeksfemales
Tokishakuyakusan ameliorates age-related pregnancy loss by modulating endocrine, inflammatory, and placental factors in an advanced maternal age rat model · Journal of ethnopharmacology · 22 Sep 2026
Progesterone
upin rats1Very low certainty
1 study
Progesterone
upin rats1Very low certainty
Tokishakuyakusan increases progesterone in rats.
Animalsadvanced maternal agediet containing 3% tokishakuyakusanplasma3%4 weeksfemales
Tokishakuyakusan ameliorates age-related pregnancy loss by modulating endocrine, inflammatory, and placental factors in an advanced maternal age rat model · Journal of ethnopharmacology · 22 Sep 2026
Placental efficiency
upin rats1Very low certainty
1 study
Placental efficiency
upin rats1Very low certainty
Tokishakuyakusan improves placental efficiency in rats.
Animalsadvanced maternal agediet containing 3% tokishakuyakusan3%4 weeksfemales
Tokishakuyakusan ameliorates age-related pregnancy loss by modulating endocrine, inflammatory, and placental factors in an advanced maternal age rat model · Journal of ethnopharmacology · 22 Sep 2026
Pregnancy loss
downin rats1Very low certainty
1 study
Pregnancy loss
downin rats1Very low certainty
Tokishakuyakusan decreases pregnancy loss in rats.
Animalsadvanced maternal agediet containing 3% tokishakuyakusan3%4 weeksfemales
Tokishakuyakusan ameliorates age-related pregnancy loss by modulating endocrine, inflammatory, and placental factors in an advanced maternal age rat model · Journal of ethnopharmacology · 22 Sep 2026
Live fetus rate
upin rats1Very low certainty
1 study
Live fetus rate
upin rats1Very low certainty
Tokishakuyakusan increases live fetus rate in rats.
Animalsadvanced maternal agediet containing 3% tokishakuyakusan3%4 weeksfemales
Tokishakuyakusan ameliorates age-related pregnancy loss by modulating endocrine, inflammatory, and placental factors in an advanced maternal age rat model · Journal of ethnopharmacology · 22 Sep 2026