Thyrotropin alfa

1. Thyrotropin alfa decreases cortisol in humans (-14.8% (SEM = 3.6%, p < 0.001)).

   “cortisol (-14.8% [SEM = 3.6%, p < 0.001] and -15.6% [SEM = 3.5%, p < 0.001])”

   Human trialhealthy older individualsintramuscular injection0.1 mg4 daysn = 29

   Effect of Thyroid Status Modulation on Pituitary and Peripheral Hormone Concentrations in Healthy Older Subjects

   Neuroendocrinology·Dec 3, 2024

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1. Thyrotropin alfa decreases prolactin in humans (-8.8% (SEM = 3.4%, p = 0.048)).

   “prolactin significantly decreased in both rhTSH and T3 challenges (-8.8% [SEM = 3.4%, p = 0.048] and -12.0% [3.3%, p = 0.004], respectively)”

   Human trialhealthy older individualsintramuscular injection0.1 mg4 daysn = 29

   Effect of Thyroid Status Modulation on Pituitary and Peripheral Hormone Concentrations in Healthy Older Subjects

   Neuroendocrinology·Dec 3, 2024

More on Prolactin

1. Thyrotropin alfa increases IGF-1 in humans (+6.3% (SEM = 1.6%, p = 0.002)).

   “IGF-1 increased with a maximum of 6.3% (SEM = 1.6%, p = 0.002) in the rhTSH challenge”

   Human trialhealthy older individualsintramuscular injection0.1 mg4 daysn = 29

   Effect of Thyroid Status Modulation on Pituitary and Peripheral Hormone Concentrations in Healthy Older Subjects

   Neuroendocrinology·Dec 3, 2024

More on IGF-1