Systemic corticosteroids
Systemic corticosteroids has been studied in 5 papers since 2020: 3 observational studies in people, 2 reviews; 2 in the past year. The newest paper, Jul 10, 2026: “Development and validation of a predictive nomogram for osteoporosis in patients with psoriasis”.
5 papers study it4 findingsUpdated
See all 5 papers on systemic corticosteroids
At a glance
The findings reach people, from one lab or study. 4 independent labs in 5 countries.
“Other independent risk factors included exposure to topical (aHR, 1.21; 95% CI, 1.05-1.39) or systemic (≥10 mg/d; aHR, 1.62; 95% CI, 1.38-1.91) corticosteroids.”
None of its findings points the other way.
- 4 independent labs in 5 countries
- Funders: European Commission and 3 more
- Humans3
What is systemic corticosteroids linked with?
4Studies link systemic corticosteroids with 4 measures, among them osteoporosis, in-hospital mortality and bone fracture.
Osteoporosis
upin humans1OR 3.501
1 study
Osteoporosis
upin humans1OR 3.501
Systemic corticosteroids are linked with a higher risk of osteoporosis in patients with psoriasis (OR 3.501, 95% CI 1.756-6.826).
“systemic corticosteroid use (OR = 3.501, 95%CI 1.756-6.826)”
Humansin patients with psoriasis
Development and validation of a predictive nomogram for osteoporosis in patients with psoriasis
Frontiers in medicine
In-hospital mortality
downin humans1
1 study
In-hospital mortality
downin humans1
Systemic corticosteroids are linked with a lower risk of in-hospital mortality in humans (critically ill COVID-19 requiring mechanical ventilation) (sHR 0.61 [95%CI 0.48-0.77]).
“systemic steroids (sHR 0.61 [95%CI 0.48- 0.77], p<0.001)”
Humanscritically ill COVID-19 requiring mechanical ventilation
Pulmonology
Bone fracture
upin humans1
1 study
Bone fracture
upin humans1
Systemic corticosteroids are linked with a higher risk of bone fracture in AD patients (aHR 1.62, 95% CI 1.38-1.91).
“Other independent risk factors included exposure to topical (aHR, 1.21; 95% CI, 1.05-1.39) or systemic (≥10 mg/d; aHR, 1.62; 95% CI, 1.38-1.91) corticosteroids.”
Humansin AD patientsbone≥10 mg/d
Fracture risks in patients with atopic dermatitis: A nationwide matched cohort study
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Fragility hip fracture
upin humans1OR 1.65
1 study
Fragility hip fracture
upin humans1OR 1.65
Systemic corticosteroids raise the risk of fragility hip fracture in humans (OR 1.65, 95% CI 1.37-1.99).
“systemic corticosteroids (OR 1.65, 95% CI 1.37-1.99)”
Review
Medications as a Risk Factor for Fragility Hip Fractures: A Systematic Review and Meta-analysis
Calcified tissue international