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SYNTA66

SYNTA66 has been studied in 1 paper since 2023: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Aug 29, 2023: “Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries”.

Intervention

1 paper studies it1 findingUpdated

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable and 3 more
  • Animals1

What did studies of SYNTA66 find?

1

Studies of SYNTA66 measured 1 outcome; the most studied are vasoconstriction (1 study).

Vasoconstriction

downin rats1

1 study

  1. SYNTA66 decreases vasoconstriction in rats.

    “Aging-related hypercontractility to serotonin and endothelin-1 in arteries from male rats was reversed by STIM/Orai inhibition with YM-58483 or by specifically blocking the Orai1 channel with Synta66.”

    Animalscoronary arteriesmales

    Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries

    International journal of molecular sciences

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