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Surfactant protein A2

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: National Heart, Lung, and Blood Institute and 2 more
  • Animals1

Outcomes

1

Actin stability

no changein mouse cells1downin mouse cells1

1 study

  1. Surfactant protein A2 has no effect on actin stability in mouse cells.

    “In vitro, SP-A2 destabilizes actin in female, but not male, mice”

    CellsSP-A knockoutpurifiedalveolar macrophagemales

    Single-cell analysis reveals differential regulation of the alveolar macrophage actin cytoskeleton by surfactant proteins A1 and A2: implications of sex and aging

    Biology of sex differencesMar 18, 2016

  2. Surfactant protein A2 decreases actin stability in mouse cells.

    “In vitro, SP-A2 destabilizes actin in female, but not male, mice”

    CellsSP-A knockoutpurifiedalveolar macrophagefemales

    Single-cell analysis reveals differential regulation of the alveolar macrophage actin cytoskeleton by surfactant proteins A1 and A2: implications of sex and aging

    Biology of sex differencesMar 18, 2016

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