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Sleep medications

Intervention

3 papers study it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funders: National Heart, Lung, and Blood Institute and others
  • Humans3

Outcomes

1

Disability

upin humans1

1 study

  1. Sleep medications increase disability in humans.

    “for every one-unit higher in the frequency of insomnia symptoms and sleep medication usage, disability scores increased by 0.20 (SE = .02, p < .001) and 0.19 (SE = .02, p < .001) every year, respectively”

    Humans5-yearn = 6,722

    Late-life disability may increase with more frequent insomnia symptoms and sleep medications use over time

    Sleep

Associations

1

Dementia

upin humans1HR 1.48

1 study

  1. Sleep medications raise the risk of dementia in humans (HR: 1.48 (95% CI: 1.26-1.74)).

    “sleep medication use compared to nonuse was associated with a 48% greater risk of dementia (HR: 1.48; 95% confidence interval (CI): 1.26-1.74).”

    Humansmedian follow-up of 6.5 years69% femalesn = 4,197

    Associations of Late-Life Sleep Medication Use With Incident Dementia in the Atherosclerosis Risk in Communities Study

    The journals of gerontology. Series A, Biological sciences and medical sciences

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