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Silicon-based agent

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Japan Science and Technology Agency and 1 more
  • Animals1

Outcomes

2

Inner ear structural damage

downin mice1

1 study

  1. Silicon-based agent decreases inner ear structural damage in mice.

    “Structural damage to the inner ear's semicircular canals and otolith organs was also reduced in Si-agents-treated group.”

    Animalsage-related vestibular declinesemicircular canal and otolith organ

    Efficacy of the silicon based agent for age related decline in vestibular function

    Scientific reports14 Aug 2025

Balance

upin mice1

1 study

  1. Silicon-based agent improves balance in mice.

    “In balance beam tests, Si-agents-treated group showed less balance decline with age compared to untreated mice.”

    Animalsage-related vestibular decline

    Efficacy of the silicon based agent for age related decline in vestibular function

    Scientific reports14 Aug 2025

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