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Senescent cell removal

Intervention

2 papers study it6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Deutsche Forschungsgemeinschaft and 6 more
  • Animals2

Outcomes

5

Survival

upin mice1

1 study

  1. Senescent cell removal improves survival in mice.

    “Partial removal of p16Ink4a-expressing malignant senescent cells, which make up less than 7 % of the tumor, modifies the tumor ecosystem and improves the survival of GBM-bearing female mice.”

    Animalsin GBM-bearing micefemales

    Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

    Nature communications

Heart rate variability

upin animals1

1 study

  1. Senescent cell removal improves heart rate variability.

    “Removal of senescent cells, which accumulated with chronological age while nerve density declined, rescued from age-induced dennervation, reduced Sema3a expression and preserved heart rate variability.”

    Animalsagingheart

    Ageing impairs the neuro-vascular interface in the heart

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

Sema3a expression

downin animals1

1 study

  1. Senescent cell removal decreases Sema3a expression.

    “Removal of senescent cells, which accumulated with chronological age while nerve density declined, rescued from age-induced dennervation, reduced Sema3a expression”

    Animalsagingheart

    Ageing impairs the neuro-vascular interface in the heart

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on Sema3a expression

Cardiac denervation

downin animals1

1 study

  1. Senescent cell removal protects against cardiac denervation.

    “Removal of senescent cells, which accumulated with chronological age while nerve density declined, rescued from age-induced dennervation”

    Animalsage-induced denervationheart

    Ageing impairs the neuro-vascular interface in the heart

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

Lifespan

upin mice1

1 study

  1. Senescent cell removal extends lifespan in mice.

    “removal of such cells alleviates many age-related diseases and extends the life span of mice”

    Review

    On the evolution of cellular senescence

    Aging cell

Associations

1

Age-related diseases

downin mice1

1 study

  1. Senescent cell removal lowers the risk of age-related diseases in mice.

    “removal of such cells alleviates many age-related diseases”

    Review

    On the evolution of cellular senescence

    Aging cell

More on Age-related diseases

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