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(s)-mk-26

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Austrian Science Fund
  • Animals1

Outcomes

3

Dopamine

upin rats1

1 study

  1. (s)-mk-26 increases dopamine in rats.

    “(S)-MK-26 significantly increased extracellular DA levels in the prefrontal cortex and in nucleus accumbens core and shell”

    Animalsprefrontal cortex and nucleus accumbens core and shell

    A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions

    BiomoleculesJun 24, 2022

More on Dopamine

Depression-like behavior

downin rats1

1 study

  1. (s)-mk-26 decreases depression-like behavior in rats.

    “(S)-MK-26 treatment reversed the depression-like behavior induced by the dopamine-depleting drug tetrabenazine (TBZ)”

    Animalstetrabenazine-induced depression-like behavior

    A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions

    BiomoleculesJun 24, 2022

synaptic plasticity

upin rats1

1 study

  1. (s)-mk-26 increases synaptic plasticity in rats.

    “Ex vivo electrophysiology revealed significantly augmented hippocampal long-term synaptic potentiation upon acute, intraperitoneally delivered (S)-MK-26 treatment”

    Animalsacute, intraperitoneally deliveredhippocampus

    A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions

    BiomoleculesJun 24, 2022

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