Rotating night shift work

Intervention1 paper2 findings

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

1 lab in 1 country

Funders: American Heart Association and 6 more

  • Humans1

Associations

2

Mortality

upin humans1HR 1.13

1 study
  1. Rotating night shift work raises the risk of mortality in humans (HR 1.13; 95% CI 1.08, 1.17).

    Humansper 5-year increasefemales

    Rotating Night Shift Work and Risk of Incident Cardiovascular Disease and Mortality by Chronotype: A Prospective Cohort Study in Nurses' Health Study II · medRxiv : the preprint server for health sciences · 17 Sep 2026 · Preprint

Cardiovascular disease

upin humans1HR 1.07

1 study
  1. Rotating night shift work raises the risk of cardiovascular disease in humans (HR 1.07; 95% CI 1.01, 1.14).

    Humansper 5-year increasefemales

    Rotating Night Shift Work and Risk of Incident Cardiovascular Disease and Mortality by Chronotype: A Prospective Cohort Study in Nurses' Health Study II · medRxiv : the preprint server for health sciences · 17 Sep 2026 · Preprint

Cardiovascular disease →

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